Methyl L-Pyroglutamate

Names

[ Name ]:
Methyl L-Pyroglutamate

[Synonym ]:
L-Pyroglutamic Acid Methyl Ester
DL-Proline, 5-oxo-, methyl ester
EINECS 225-567-3
Methyl (S)-(+)-2-Pyrrolidone-5-carboxylate
methyl (2S)-5-oxopyrrolidine-2-carboxylate
(S)-5-Oxopyrrolidine-2-carboxylic Acid Methyl Ester
MFCD00080931
Methyl (S)-5-Oxopyrrolidine-2-carboxylate
L-Proline, 5-oxo-, methyl ester
Methyl 5-oxo-L-prolinate
L-Pyroglutamic acid methylester

Biological Activity

[Description]:

Methyl L-pyroglutamate ((S)-Methyl 5-oxopyrrolidine-2-carboxylate;L-Pyroglutamic acid methyl ester) is isolated from P. oleracea and has anti-inflammatory activity[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Kim KH, et al. 1-Carbomethoxy-β-Carboline, Derived from Portulaca oleracea L., Ameliorates LPS-Mediated Inflammatory Response Associated with MAPK Signaling and Nuclear Translocation of NF-κB.Molecules. 2019 Nov 7;24(22). pii: E4042.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
304.7±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₉NO₃

[ Molecular Weight ]:
143.141

[ Flash Point ]:
138.1±25.9 °C

[ Exact Mass ]:
143.058243

[ PSA ]:
55.40000

[ LogP ]:
-1.92

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.465

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933790090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%