<Suppliers Price>

Nicotelline

Names

[ CAS No. ]:
494-04-2

[ Name ]:
Nicotelline

[Synonym ]:
2,4-dipyridin-3-ylpyridine

Biological Activity

[Description]:

Nicotelline (Nicotellin) is a nicotine-related alkaloid, as well as a weak inhibitor of human cDNA-expressed cytochrome P-450 2A6 (CYP2A6). CYP2A6 mediates coumarin 7-hydroxylation, while Nicotelline fails to exhibit inhibition at 300 μM. Nicotelline can be used as a tracer and biomarker of particulate matter (PM) derived from tobacco smoke[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Research Areas >> Neurological Disease

[Target]

CYP26:≥300 μM (Ki)


[References]

[1]. Denton TT, et al. Nicotine-related alkaloids and metabolites as inhibitors of human cytochrome P-450 2A6. Biochem Pharmacol. 2004 Feb 15;67(4):751-6.  

[2]. Jacob P 3rd, et al. Nicotelline: a proposed biomarker and environmental tracer for particulate matter derived from tobacco smoke. Chem Res Toxicol. 2013 Nov 18;26(11):1615-31.  

Chemical & Physical Properties

[ Density]:
1.168 g/cm3

[ Boiling Point ]:
416.8ºC at 760 mmHg

[ Melting Point ]:
147-149ºC

[ Molecular Formula ]:
C15H11N3

[ Molecular Weight ]:
233.27

[ Flash Point ]:
190.9ºC

[ Exact Mass ]:
235.11100

[ PSA ]:
37.81000

[ LogP ]:
2.97270

[ Vapour Pressure ]:
9.02E-07mmHg at 25°C

[ Index of Refraction ]:
1.615

[ Storage condition ]:
-20°C

Precursor & DownStream

Precursor

DownStream

Related Compounds