<Suppliers Price>

Org 25543 hydrochloride

Names

[ CAS No. ]:
495076-64-7

[ Name ]:
Org 25543 hydrochloride

[Synonym ]:
4-(Benzyloxy)-N-{[1-(dimethylamino)cyclopentyl]methyl}-3,5-dimethoxybenzamide hydrochloride (1:1)
Benzamide, N-[[1-(dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-(phenylmethoxy)-, hydrochloride (1:1)
MFCD23701926

Biological Activity

[Description]:

Org 25543 hydrochloride is a selective and irreversible GlyT2 inhibitor (IC50: 16 nM). Org 25543 hydrochloride has analgesia effect. Org 25543 hydrochloride ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice[1][2][3].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> GlyT

[References]

[1]. Caulfield WL, et al. The first potent and selective inhibitors of the glycine transporter type 2. J Med Chem. 2001 Aug 16;44(17):2679-82.  

[2]. Morita K, et al. Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J Pharmacol Exp Ther. 2008 Aug;326(2):633-45.  

[3]. Mohammadzadeh A, et al. Pharmacological Evidence on Augmented Antiallodynia Following Systemic Co-Treatment with GlyT-1 and GlyT-2 Inhibitors in Rat Neuropathic Pain Model. Int J Mol Sci. 2021 Mar 1;22(5):2479.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H33ClN2O4

[ Molecular Weight ]:
448.98

[ Exact Mass ]:
448.212891

Related Compounds