ML-099

Names

[ Name ]:
ML-099

[Synonym ]:
2-[(2-Phenylethyl)sulfanyl]nicotinic acid
3-Pyridinecarboxylic acid, 2-[(2-phenylethyl)thio]-

Biological Activity

[Description]:

ML-099 (CID-888706) is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, Rab7, and Rab-2A[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Ras

[In Vitro]

ML-099 activates cell division cycle 42 activated mutant, cell division cycle 42 wild type, Ras protein wild type, GTP-binding protein (Rab7), Rab-2A, Rac1 protein activated mutant, Rac1 protein wild type, and Ras protein activated mutant with EC50 values of 58.88 nM, 100 nM, 141.25 nM, 181.97 nM, 354.81 nM, 25.42 nM, 20.17 nM and 95.5 nM, respectively[1].

[References]

[1]. Surviladze, Z., et al. UNMCMD Probe Report: Three small molecule pan activator families of Ras-related GTPases. 1-42 (2010-2009 May 18).

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
449.1±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₃NO₂S

[ Molecular Weight ]:
259.323

[ Flash Point ]:
225.4±27.3 °C

[ Exact Mass ]:
259.066711

[ PSA ]:
75.49000

[ LogP ]:
3.43

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.646

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933399090

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%