HhAntag

Names

[ Name ]:
HhAntag

[Synonym ]:
CS-1233
GLI1-mediated tranion inhibitor
HhAntag

Biological Activity

[Description]:

HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway; antitumor agent.IC50 value:Target: Gli

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Gli

Research Areas >> Cancer

[References]

[1]. Actis, Marcelo; Connelly, Michele C.; Mayasundari, Anand et al. A structure-activity relationship study of small-molecule inhibitors of GLI1-mediated transcription. Biopolymers (2011), 95(1), 24-30.

[2]. Mahindroo, Neeraj; Connelly, Michele C.; Punchihewa, Chandanamali; et al. Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway. Bioorganic & Medicinal Chemistry (2010), 18(13), 4801-4811.

[3]. Yauch, Robert L.; Gould, Stephen E.; Scales, Suzie J.; et al. A paracrine requirement for hedgehog signalling in cancer. Nature (London, United Kingdom) (2008), 455(7211), 406-410.

[Related Small Molecules]

GANT 61 | GANT58

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₃ClN₄O₃

[ Molecular Weight ]:
450.91700

[ Exact Mass ]:
450.14600

[ PSA ]:
82.97000

[ LogP ]:
5.60280

[ Storage condition ]:
2-8℃