g418

Names

[ Name ]:
g418

[Synonym ]:
Gentamicin G-418
Gentamycin B
(2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol
Betamicina [INN-Spanish]
Gentamicin B
Betamicina
BETAMICIN
Betamicinum [INN-Latin]
Betamicine [INN-French]
Betamicin [INN]

Biological Activity

[Description]:

G-418 (Geneticin) is an aminoglycoside antibiotic with a structure similar to gentamicin. It is toxic to both eukaryotic and prokaryotic cells and works by interfering with protein synthesis[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

G-418 (500 μg/mL，12 days) 用于筛选耐药性 LNCaP 细胞[1]。

[References]

[1]. S Bennett, et al. Reliable method of isolating transfected clones from the LNCaP human prostatic cell line. Biotechniques. 1997 Jul;23(1):66, 68, 70.

Chemical & Physical Properties

[ Density]:
1.47 g/cm3

[ Boiling Point ]:
760.3ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₄₀N₄O₁₀

[ Molecular Weight ]:
496.55200

[ Flash Point ]:
413.6ºC

[ Exact Mass ]:
496.27400

[ PSA ]:
248.39000

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: 50 mg/mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WK2132600

CHEMICAL NAME :: D-Streptamine, O-2-amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopy ranosyl-(1-4)-O- (3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyr anosyl-(1-6))-

CAS REGISTRY NUMBER :: 49863-47-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H40-N4-O10

MOLECULAR WEIGHT :: 496.64

WISWESSER LINE NOTATION :: T6OTJ CZ DQ EQ FYQ1 BO- BL6TJ AZ CQ EZ DO- BT6OTJ CQ DM1 EQ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Fibroblast

DOSE/DURATION :: 75 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 21,67,1993

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
22-24/25

[ WGK Germany ]:
3