Lutidinic acid

Names

[ CAS No. ]:
499-80-9

[ Name ]:
Lutidinic acid

[Synonym ]:
2,4-Pyridinedicarboxylic acid
EINECS 207-892-2
MFCD00006296
2,4-Lutidinic Acid
Pyridine-2,4-dicarboxylic acid
Lutidinic acid

Biological Activity

[Description]:

2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenase, including JmjC domain-containing family of histone demethylases (JHDMs). 2,4-PDCA is a target chemical in the field of bio-based plastics[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Demethylase

[References]

[1]. Brewitz L, et al. Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases. J Fluor Chem. 2021 Jul;247:109804.

[2]. Gómez-Álvarez H, et al. Bioconversion of lignin-derived aromatics into the building block pyridine 2,4-dicarboxylic acid by engineering recombinant Pseudomonas putida strains. Bioresour Technol. 2022 Feb;346:126638.

[3]. Brewitz L, et al. Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases. J Fluor Chem. 2021 Jul;247:109804.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
574.8±35.0 °C at 760 mmHg

[ Melting Point ]:
243-246 °C

[ Molecular Formula ]:
C₇H₅NO₄

[ Molecular Weight ]:
167.12

[ Flash Point ]:
301.4±25.9 °C

[ Exact Mass ]:
167.021851

[ PSA ]:
87.49000

[ LogP ]:
-0.19

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.628

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ HS Code ]:
29333999

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%