17-Beta-Estradiol-3-O-Sulfate Sodium

Names

[ Name ]:
17-Beta-Estradiol-3-O-Sulfate Sodium

[Synonym ]:
b-Estradiol 3-sulfate sodium salt
Estra-1,3,5(10)-triene-3,17-diol, 3-(hydrogen sulfate), sodium salt, (17β)- (1:1)
17BETA-ESTRADIOL 3-SULFATE SODIUM
17BETA-ESTRADIOL 3-SULFATE SODIUM SALT
SODIUM 17B-ESTRADIOL 3-SULFATE
oestradiol 3-sulfate,sodium salt
17B-estradiol 3-sulfate sodium
17Beta-Estradiol 3-O-Sulfate Sodium Salt
Sodium (17β)-17-hydroxyestra-1,3,5(10)-trien-3-yl sulfate

Biological Activity

[Description]:

17β-Estradiol sulfate (sodium), also known as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[In Vitro]

17β-Estradiol sulfate (sodium) is a neuroactive steroid[1][2].

[References]

[1]. Li W, et al. Neuroactive steroids and human recombinant rho1 GABAC receptors. J Pharmacol Exp Ther. 2007;323(1):236-247.

[2]. Schneider C, et al. A novel enzyme-linked immunosorbent assay for ethynylestradiol using a long-chain biotinylated EE2 derivative. Steroids. 2004;69(4):245-253.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₃NaO₅S

[ Molecular Weight ]:
374.427

[ Exact Mass ]:
374.116394

[ PSA ]:
95.04000

[ LogP ]:
3.82340

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H332-H351

[ Precautionary Statements ]:
P281

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
22-36

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Sulfotransferase 2A1 forms estradiol-17-sulfate and celecoxib switches the dominant product from estradiol-3-sulfate to estradiol-17-sulfate.

J. Steroid Biochem. Mol. Biol. 96(5) , 367-74, (2005)

Using recombinant sulfotransferases (SULTs) expressed in E. coli, beta-estradiol (E2) sulfonation was examined to determine which SULT enzyme is responsible for producing E2-17-sulfate (E2-17-S). SULT...

Steroid sulphate secretion by the human ovary in vitro: influence of gonadotrophins, cyclofenil and clomiphene.

J. Steroid Biochem. 13(12) , 1401-6, (1980)

[Evidence, in vitro, of estrone and estradiol-17 beta 3-sulfoconjugate hydrolysis in the uterus of pregnant guinea pigs].

C. R. Seances. Acad. Sci. III. 292(9) , 609-12, (1981)

The metabolism, in vitro, of [6,7-3H]-oestrone-3-sulfate and [6,7-3H]-oestradiol-17beta-3-sulfate by the uteri of pregnant female Guinea-Pigs has been studied using 900 g supernatants. A hydrolysis of...