D-Ribose

Names

[ CAS No. ]:
50-69-1

[ Name ]:
D-Ribose

[Synonym ]:
RIBOSE,D-(-)
FEMA 3793
EINECS 200-059-4
D-RIB
(2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal
D-Ribose
d-ribos
D-(-)-RIBOSE
Ribose (300 mg)
R-RIBOSE
D-(−)-Ribose
ribose,pure
MFCD00135453

Biological Activity

[Description]:

D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism[1]. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner[1].

[References]

[1]. Hong J, et al. D-ribose induces nephropathy through RAGE-dependent NF-κB inflammation. Arch Pharm Res. 2018 Aug;41(8):838-847.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
415.5±38.0 °C at 760 mmHg

[ Melting Point ]:
88-92ºC

[ Molecular Formula ]:
C₅H₁₀O₅

[ Molecular Weight ]:
150.13

[ Flash Point ]:
219.2±23.3 °C

[ Exact Mass ]:
150.052826

[ PSA ]:
97.99000

[ LogP ]:
-2.39

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.544

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VJ2275000

CHEMICAL NAME :: Ribose, D-

CAS REGISTRY NUMBER :: 50-69-1

BEILSTEIN REFERENCE NO. :: 1723081

LAST UPDATED :: 199801

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C5-H10-O5

MOLECULAR WEIGHT :: 150.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intrauterine

DOSE :: 5045 ug/kg

SEX/DURATION :: female 2 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 30 mmol/L

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 180,246,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1001 No. of Facilities: 439 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 4169 (estimated) No. of Female Employees: 2111 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
F

[ Risk Phrases ]:
R36/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
VJ2275000

[ HS Code ]:
2940000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2912491000

[ Summary ]:
2912491000. other aldehyde-alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

High-throughput electrophoretic mobility shift assays for quantitative analysis of molecular binding reactions.

Anal. Chem. 86(20) , 10357-64, (2014)

We describe a platform for high-throughput electrophoretic mobility shift assays (EMSAs) for identification and characterization of molecular binding reactions. A photopatterned free-standing polyacry...

TLR signaling modulates side effects of anticancer therapy in the small intestine.

J. Immunol. 194(4) , 1983-95, (2015)

Intestinal mucositis represents the most common complication of intensive chemotherapy, which has a severe adverse impact on quality of life of cancer patients. However, the precise pathophysiology re...

Simplified in vitro refolding and purification of recombinant human granulocyte colony stimulating factor using protein folding cation exchange chromatography.

J. Chromatogr. A. 1379 , 74-82, (2015)

Protein folding-strong cation exchange chromatography (PF-SCX) has been employed for efficient refolding with simultaneous purification of recombinant human granulocyte colony stimulating factor (rhG-...