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Nsc61610

Names

[ CAS No. ]:
500538-94-3

[ Name ]:
Nsc61610

Biological Activity

[Description]:

NSC61610 disrupts hIL-18 binding to the ectromelia virus IL-18BP. NSC61610 inhibits hIL-18:ectvIL-18BP complex formation with an IC50 about 6 uM[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Research Areas >> Inflammation/Immunology

[In Vitro]

NSC61610 在 β 链 β5 和 β8 之间的 hIL-18 中的预测 Ki 值为 88 nM (虚拟筛选)[1]。 NSC61610 抑制 hIL-18:ectvIL-18BP 复合物形成,IC50 约为 6 uM[1]。

[References]

[1]. Krumm B, et al. Identification of small molecule inhibitors of Interleukin-18. Sci Rep. 2017 Mar 28;7(1):483.  

Chemical & Physical Properties

[ Molecular Formula ]:
C34H24N6O2

[ Molecular Weight ]:
548.59


Related Compounds