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Demethoxydeacetoxypseudolaric acid B analog

Names

[ CAS No. ]:
500736-17-4

[ Name ]:
Demethoxydeacetoxypseudolaric acid B analog

[Synonym ]:
1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylic acid, 3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-4a-hydroxy-3-methyl-1-oxo-, (3R,4R,4aS,9aR)-
(1R,7S,8R,9R)-9-[(1E,3E)-4-Carboxy-1,3-pentadien-1-yl]-7-hydroxy-9-methyl-11-oxo-10-oxatricyclo[6.3.2.0]tridec-3-ene-4-carboxylic acid

Biological Activity

[Description]:

Demethoxydeacetoxypseudolaric acid B analog (Compound 13b) is semi-synthesized by efficient routines from Pseudolaric acid B. It has potent activities against HMEC-1, HL-60, A-549, MB-MDA-468, BEL-7402, HCT116, and Hela cells with IC50s ranging from 0.136 to 1.162 μM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Yang SP, et al. Structural modification of an angiogenesis inhibitor discovered from traditional Chinese medicineand a structure-activity relationship study. J Med Chem. 2008 Jan 10;51(1):77-85.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
665.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H30O8

[ Molecular Weight ]:
376.400

[ Flash Point ]:
238.2±25.0 °C

[ Exact Mass ]:
376.152191

[ LogP ]:
1.41

[ Vapour Pressure ]:
0.0±4.6 mmHg at 25°C

[ Index of Refraction ]:
1.613

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds