Cucurbitacin IIB

Names

[ Name ]:
Cucurbitacin IIB

[Synonym ]:
19-Norlanost-5-ene-11,22-dione, 2,3,16,20,25-pentahydroxy-9-methyl-, (2β,3α,9β,10α,16α)-
(1S,2S,4R,9β,16α)-1,2,16,20,25-Pentahydroxy-9,10,14-trimethyl-4,9-cyclo-9,10-secocholest-5-ene-11,22-dione
25-deacetyl hemslecin A
22,23-dihydrocucurbitacin F
Estr-5-en-11-one, 17-[(1R)-1,5-dihydroxy-1,5-dimethyl-2-oxohexyl]-2,3,16-trihydroxy-4,4,9,14-tetramethyl-, (2β,3α,9β,10α,16α,17β)-
23,24-Dihydrocucurbitacin F
dihydrocucurbitacin F
CucurbitacinⅡb
Cucurbitacin Ⅱb

Biological Activity

[Description]:

Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Inflammation/Immunology

[References]

[1]. Wang Y, et al. Cucurbitacin IIb exhibits anti-inflammatory activity through modulating multiple cellular behaviors of mouse lymphocytes. PLoS One. 2014 Feb 25;9(2):e89751.

Chemical & Physical Properties

[ Density]:
1.22±0.1 g/cm3

[ Boiling Point ]:
668.4±55.0 °C at 760 mmHg

[ Melting Point ]:
158-159ºC

[ Molecular Formula ]:
C₃₀H₄₈O₇

[ Molecular Weight ]:
520.698

[ Flash Point ]:
372.0±28.0 °C

[ Exact Mass ]:
520.340027

[ PSA ]:
135.29000

[ LogP ]:
1.92

[ Vapour Pressure ]:
0.0±4.6 mmHg at 25°C

[ Index of Refraction ]:
1.577

[ Storage condition ]:
2-8°C

Cucurbitacin IIB

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds