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Vasicinol

Names

[ CAS No. ]:
5081-51-6

[ Name ]:
Vasicinol

[Synonym ]:
(3R)-1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazoline-3,7-diol
Pyrrolo[2,1-b]quinazoline-3,7-diol, 1,2,3,9-tetrahydro-, (3S)-
Pyrrolo[2,1-b]quinazoline-3,7-diol, 1,2,3,9-tetrahydro-, (3R)-
Pyrrolo(2,1-b)quinazoline-3,7-diol, 1,2,3,9-tetrahydro-, (R)-
(3S)-1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazoline-3,7-diol

Biological Activity

[Description]:

Vasicinol is a reversible inhibitor of sucrase (IC50: 250 μM). Vasicinol is a HbF inducer. Vasicinol also inhibits Angiotensin-converting Enzyme (ACE). Vasicinol is apyrroquinazoline alkaloid that can be isolated from Adhatoda vasica[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)

[References]

[1]. Gao H, et al. Inhibitory effect on α-glucosidase by Adhatoda vasica Nees. Food Chem. 2008 Jun 1;108(3):965-72.  

[2]. Tehreem S, et al. A UPLC-DAD-Based Bio-Screening Assay for the Evaluation of the Angiotensin Converting Enzyme Inhibitory Potential of Plant Extracts and Compounds: Pyrroquinazoline Alkaloids from Adhatoda vasica as a Case Study. Molecules. 2021 Nov 18;26(22):6971.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
465.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H12N2O2

[ Molecular Weight ]:
204.23

[ Flash Point ]:
235.1±31.5 °C

[ Exact Mass ]:
204.089874

[ PSA ]:
56.06000

[ LogP ]:
-1.73

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.743

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds