substance P (3-11)

Names

[ Name ]:
substance P (3-11)

[Synonym ]:
L-Lysinamide, L-methionyl-L-leucylglycyl-L-phenylalanyl-L-phenylalanyl-L-glutaminyl-L-glutaminyl-L-prolyl-
L-Methionyl-L-leucylglycyl-L-phenylalanyl-L-phenylalanyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-lysinamide

Biological Activity

[Description]:

Substance P (3-11) is a substance P (SP) fragment peptide that can cross the BBB. Substance P (3-11) has contracting activities on guinea pig ileum. Substance P (3-11) also promotes human monocyte chemotaxis [1][2][5].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

Substance P (3-11) 可渗透 BBMEC 单层，渗透速率为 1.92 x 105 cm/s[2] Substance P (3-11) 在改进的 Boyden 室试验中促进人单核细胞趋化性[3]

[In Vivo]

Substance P (3-11) (30 nmol/kg，静脉输注) 增加大鼠血浆中组胺水平[4]

[References]

[1]. Yanaihara N, et al. Immunological aspects of secretin, substance P, and VIP. Gastroenterology. 1977 Apr;72(4 Pt.2):803-10.

[2]. Chappa AK, et al. Characteristics of substance P transport across the blood-brain barrier. Pharm Res. 2006 Jun;23(6):1201-8.

[3]. Ruff MR, et al. Substance P receptor-mediated chemotaxis of human monocytes. Peptides. 1985;6 Suppl 2:107-11.

[4]. Sertl K, et al. Substance P: the relationship between receptor distribution in rat lung and the capacity of substance P to stimulate vascular permeability. Am Rev Respir Dis. 1988 Jul;138(1):151-9.