Glufosinate

Names

[ Name ]:
Glufosinate

[Synonym ]:
2-amino-4-(hydroxymethylphosphinyl)butyric acid
(2RS)-2-amino-4-[hydroxy(methyl)phosphinoyl]butyric acid
4-[hydroxy(methyl)phosphinoyl]-DL-homoalanine
2-amino-4-(hydroxymethylphosphinyl)butanoic acid
glufosinate

Biological Activity

[Description]:

Glufosinate, a phosphinic acid analogue of glutamic acid, is a herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate exerts neurotoxic activity[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

Glufosinate (1-100 μM; 12DIV) disrupts cell-cell adhesion in differentiated V-SVZ neural stem cells (NSCs)[2]. Glufosinate (1-100 μM; 12DIV) significantly decreases Celsr2 gene expression at 100 μM[2]. Glufosinate impairs ependymal cell capability to synthetize cilia[2].

[In Vivo]

Glufosinate (10-250 mg/kg; gavage; Daily; on days 6-15 of gestation) indicates maternal toxicity in the groups given 50 or 250 mg/kg in Wistar rats[3]. The Elimination of Glufosinate (oral intubation) in the blood takes place with a half-life of less than 4 hours in male and female rats[3].

[References]

[1]. Áy Z, et al. The effect of high concentrations of glufosinate ammonium on the yield components of transgenic spring wheat (Triticum aestivum L.) constitutively expressing the bar gene. ScientificWorldJournal. 2012;2012:657945.

[2]. Feat-Vetel J, et al. Multiple effects of the herbicide glufosinate-ammonium and its main metabolite on neural stem cells from the subventricular zone of newborn mice. Neurotoxicology. 2018 Dec;69:152-163.

[3]. Ebert E, et al. Summary of safety evaluation toxicity studies of glufosinate ammonium. Food Chem Toxicol. 1990 May;28(5):339-49.

Chemical & Physical Properties

[ Density]:
1.378 g/cm3

[ Boiling Point ]:
519.1ºC at 760 mmHg

[ Melting Point ]:
230ºC

[ Molecular Formula ]:
C₅H₁₂NO₄P

[ Molecular Weight ]:
181.12700

[ Flash Point ]:
267.7ºC

[ Exact Mass ]:
181.05000

[ PSA ]:
110.43000

[ LogP ]:
0.38890

[ Index of Refraction ]:
1.5

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2931900090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%