abietic acid

Names

[ CAS No. ]:
514-10-3

[ Name ]:
abietic acid

[Synonym ]:
Abietic acid
EINECS 208-178-3
7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthrene-1-carboxylic acid
7,13-Abietadien-18-oic acid
1,1-Dimethyl-7-isopropyl-1,2,3,4-tetrahydro-phenanthren
Sylvic Acid
abieta-7,13-diene-18-oic acid
MFCD03423567
simonellite
abieta-7,13-dien-18-oic acid
7-Isopropyl-1,1-dimethyl-1,2,3,4-tetrahydro-phenanthren
7-isopropyl-1,1-dimethyl-1,2,3,4-tetrahydro-phenanthrene

Biological Activity

[Description]:

Abietic acid, a diterpene isolated from Pimenta racemosa var. grissea, possesses antiproliferative, antibacterial, and anti-obesity properties. Abietic acid inhibits lipoxygenase activity for allergy treatment[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[References]

[1]. Ulusu NN, et al. Abietic acid inhibits lipoxygenase activity. Phytother Res. 2002 Feb;16(1):88-90.

[2]. Fernández MA, et al. Anti-inflammatory activity of abietic acid, a diterpene isolated from Pimenta racemosa var. grissea. J Pharm Pharmacol. 2001 Jun;53(6):867-72.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
439.5±44.0 °C at 760 mmHg

[ Melting Point ]:
139-142 °C(lit.)

[ Molecular Formula ]:
C₂₀H₃₀O₂

[ Molecular Weight ]:
302.451

[ Flash Point ]:
208.1±23.1 °C

[ Exact Mass ]:
302.224579

[ PSA ]:
37.30000

[ LogP ]:
6.51

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.542

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TP8580000

CHEMICAL NAME :: Podocarpa-7,13-dien-15-oic acid, 13-isopropyl-

CAS REGISTRY NUMBER :: 514-10-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C20-H30-O2

MOLECULAR WEIGHT :: 302.50

WISWESSER LINE NOTATION :: L B666 EU GUTJ A1 EY1&1 KVQ K1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02819 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2302 No. of Facilities: 5012 (estimated) No. of Industries: 34 No. of Occupations: 47 No. of Employees: 31118 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2302 No. of Facilities: 171 (estimated) No. of Industries: 5 No. of Occupations: 11 No. of Employees: 3942 (estimated) No. of Female Employees: 646 (estimated)

Safety Information

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
UN 3077 9/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
TP8580000

[ Hazard Class ]:
9.0

[ HS Code ]:
2916209090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916209090

[ Summary ]:
2916209090 other cyclanic, cyclenic or cyclotherpenic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%