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Purpurogallin carboxylic acid

Names

[ CAS No. ]:
5146-12-3

[ Name ]:
Purpurogallin carboxylic acid

[Synonym ]:
PJSKCCANFAFYHW-UHFFFAOYSA
2,3,4,6-tetrahydroxy-5-oxo-5h-benzo[7]annulene-8-carboxylic acid

Biological Activity

[Description]:

Purpurogallin carboxylic acid, isolated from Macleaya microcarpa (Maxim.) Fedde, is an oxidation product of gallic acid in fermented tea. Purpurogallin carboxylic acid has anti-cancer activity[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Purpurogallin carboxylic acid has an inhibitory effect towards breast (MCF7) and lung (A549) cancer cell lines[2].

[References]

[1]. Jhoo, J.W, et al. Anti-inflammatory Effects of Purpurogallin Carboxylic Acid, An Oxidation Product of Gallic Acid in Fermented Tea.

[2]. Rambabu M, et al. Virtual screening of National Cancer Institute database for claudin-4 inhibitors: Synthesis, biological evaluation, and molecular dynamics studies. J Cell Biochem. 2018 Nov 26.

Chemical & Physical Properties

[ Density]:
1.93g/cm3

[ Boiling Point ]:
327.3ºC at 760 mmHg

[ Molecular Formula ]:
C12H8O7

[ Molecular Weight ]:
264.18800

[ Flash Point ]:
166ºC

[ Exact Mass ]:
264.02700

[ PSA ]:
135.29000

[ LogP ]:
0.72060

[ Index of Refraction ]:
1.819

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds