5-bromo-N-(2-morpholinoethyl)nicotinamide

Names

[ Name ]:
5-bromo-N-(2-morpholinoethyl)nicotinamide

[Synonym ]:
3-Pyridinecarboxamide, 5-bromo-N-[2-(4-morpholinyl)ethyl]-
5-bromo-N-[2-(morpholin-4-yl)ethyl]pyridine-3-carboxamide
MFCD04225865
5-Bromo-N-[2-(4-morpholinyl)ethyl]nicotinamide

Biological Activity

[Description]:

WAY-620147 (compound 6) is an N-(2-morpholinoethyl)nicotinamide derivative that inhibits monoamine oxidase (Monoamine Oxidase). WAY-620147 inhibits MAO-A and MAO-B with IC50s of 26 μM and 55 μM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Neurological Disease

[Target]

IC50: 26 μM (MAO-A), 55 μM (MAO-B)[1]

[References]

[1]. Shi L, et al. Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
465.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₆BrN₃O₂

[ Molecular Weight ]:
314.178

[ Flash Point ]:
235.3±28.7 °C

[ Exact Mass ]:
313.042572

[ LogP ]:
0.49

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.567