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4-Methoxylonchocarpin

Names

[ CAS No. ]:
51589-67-4

[ Name ]:
4-Methoxylonchocarpin

[Synonym ]:
4-methoxylonchocarpin
(E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-methoxy-phenyl)-propenone
1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-methoxyphenyl)-propenone

Biological Activity

[Description]:

4-Methoxylonchocarpin is an orally active anti-inflammatory agent. 4-methoxylonchocarpin inhibits the binding of LPS to Toll-like Receptor (TLR) TLR4 to inhibit NF-κB activation and TNF Receptor and IL-6 expression. 4-Methoxylonchocarpin also inhibits the phosphorylation of TGF-beta activated kinase 1 and TNBS-induced expression of IL-1β, IL-17A, and TNF. 4-methoxylonchocarpin can improve 2,4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Research Areas >> Inflammation/Immunology

[References]

[1]. Jang HM, et al. 4-Methoxylonchocarpin attenuates inflammation by inhibiting lipopolysaccharide binding to Toll-like receptor of macrophages and M1 macrophage polarization. Int Immunopharmacol. 2017 Apr;45:90-97.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H20O4

[ Molecular Weight ]:
336.38

[ Exact Mass ]:
336.13600

[ PSA ]:
55.76000

[ LogP ]:
4.48110

Related Compounds