Cycloguanil

Names

[ CAS No. ]:
516-21-2

[ Name ]:
Cycloguanil

[Synonym ]:
Cycloguanyl
Cycloguanil
1-(4-chloro-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diyldiamine
Chlorcycloguanil
WR 5473
Chlorguanide triazine
1-(4-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-1,3,5-triazine
1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine
1-(p-Chlorophenyl)-4,6-diamino-2,2-dimethyl-1,2-dihydro-s-triazine
1-(4-Chlor-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazin-2,4-diyldiamin

Biological Activity

[Description]:

Cycloguanil, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

[References]

[1]. Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105(1):190-200.

Chemical & Physical Properties

[ Density]:
1.4g/cm3

[ Boiling Point ]:
400.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₁₄ClN₅

[ Molecular Weight ]:
251.71500

[ Flash Point ]:
196.1ºC

[ Exact Mass ]:
251.09400

[ PSA ]:
75.00000

[ LogP ]:
2.86690

Safety Information

[ HS Code ]:
2933699090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933699090

[ Summary ]:
2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%