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(Sar1)-Angiotensin II

Names

[ CAS No. ]:
51833-69-3

[ Name ]:
(Sar1)-Angiotensin II

[Synonym ]:
(Sar1)-Angiotensin II

Biological Activity

[Description]:

(Sar1)-Angiotensin II, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. (Sar1)-Angiotensin II binds to brain membrane-rich particles, with a Kd of 2.7 nM. (Sar1)-Angiotensin II can stimulate protein synthesis and cell growth in embryonic chick myocytes[1][2][3].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor

[In Vitro]

(Sar1)-Angiotensin II (1 μM/day; 9 d) increases the total protein content in embryonic chick myocytes by 18.5, 26.2, and 22.2% at 5, 7, and 9 days, respectively[2]. (Sar1)-Angiotensin II binds to brain membrane-rich particles in cynomolgus monkey brain, with a Kd of 2.7 nM[3].

[References]

[1]. Matsoukas JM, et, al. Differences in backbone structure between angiotensin II agonists and type I antagonists. J Med Chem. 1995 Nov 10;38(23):4660-9.

[2]. Aceto JF, et, al. [Sar1]angiotensin II receptor-mediated stimulation of protein synthesis in chick heart cells. Am J Physiol. 1990 Mar;258(3 Pt 2):H806-13.

[3]. Millan MA, et, al. Distribution of angiotensin II receptors in the brain of nonhuman primates. Peptides. Mar-Apr 1990;11(2):243-53.

Chemical & Physical Properties

[ Molecular Formula ]:
C49H71N13O10

[ Molecular Weight ]:
1002.17000

[ Exact Mass ]:
1001.54000

[ PSA ]:
355.05000

[ LogP ]:
3.17750

Related Compounds