DAO-IN-1

Names

[ Name ]:
DAO-IN-1

Biological Activity

[Description]:

DAO-IN-1 is a potent inhibitor of D-amino acid oxidase (DAO) with an IC50 value of 269 nM. DAO is an enzyme responsible for D-serine metabolism, D-serine is a co-agonist of NMDA receptors[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[Target]

D-amino acid oxidase (DAO)[1]

[References]

[1]. Sparey T, et al. The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3386-91.

Chemical & Physical Properties

[ Density]:
1.609 g/cm3

[ Boiling Point ]:
437.4ºC at 760 mmHg

[ Molecular Formula ]:
C₇H₅NO₂S

[ Molecular Weight ]:
167.19

[ Flash Point ]:
218.3ºC

[ Exact Mass ]:
167.00400

[ PSA ]:
81.33000

[ LogP ]:
1.92760

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%