Schaftoside

Names

[ CAS No. ]:
51938-32-0

[ Name ]:
Schaftoside

[Synonym ]:
4H-1-Benzopyran-4-one, 8-(D-arabinopyranosyloxy)-6-(D-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-
Shaftoside
Apigenin 8-C-|A-L-arabinoside 6-C-|A-D-glucoside
Schaftoside
5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-8-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]chromen-4-one
8-(D-Arabinopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-6-yl D-glucopyranoside
schaftozide

Biological Activity

[Description]:

Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)

Signaling Pathways >> Immunology/Inflammation >> MyD88

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> Mitochondrial Metabolism

Signaling Pathways >> Cytoskeleton >> Dynamin

[In Vitro]

Schaftoside inhibits three pro-inflammatory enzymatic activities: secretory phospholipase A2 (sPLA2), lipoxygenase (LOX), and cyclooxygenase 2 (COX-2). Schaftoside also inhibits mRNA and protein expressions of proinflammatory cytokines(IL-1β, TNF-α, and IL-6)[1].

[References]

[1]. Zhou K, et al. Schaftoside ameliorates oxygen glucose deprivation-induced inflammation associated with the TLR4/Myd88/Drp1-related mitochondrial fission in BV2 microglia cells. J Pharmacol Sci. 2019 Jan;139(1):15-22.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
1028.2±65.0 °C at 760 mmHg

[ Melting Point ]:
228ºC

[ Molecular Formula ]:
C₂₆H₂₈O₁₄

[ Molecular Weight ]:
564.49

[ Flash Point ]:
342.7±27.8 °C

[ Exact Mass ]:
596.137756

[ PSA ]:
269.43000

[ LogP ]:
-3.06

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.754

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
DJ2977250

[ HS Code ]:
29389090