Hydroxy-PEG2-CH2COOH

Names

[ CAS No. ]:
51951-04-3

[ Name ]:
Hydroxy-PEG2-CH2COOH

[Synonym ]:
[2-(2-Hydroxyethoxy)ethoxy]acetic acid
MFCD20640451
Acetic acid, 2-[2-(2-hydroxyethoxy)ethoxy]-

Biological Activity

[Description]:

Hydroxy-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.2±0.0 g/cm3

[ Boiling Point ]:
343.4±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₁₂O₅

[ Molecular Weight ]:
164.156

[ Flash Point ]:
144.3±0.0 °C

[ Exact Mass ]:
164.068466

[ LogP ]:
-1.73

[ Vapour Pressure ]:
0.0±0.0 mmHg at 25°C

[ Index of Refraction ]:
1.462

Hydroxy-PEG2-CH2COOH

Names

Biological Activity

Chemical & Physical Properties

Related Compounds