Chloro-PEG5-chloride

Names

[ Name ]:
Chloro-PEG5-chloride

[Synonym ]:
3,6,9,12-Tetraoxatetradecane,1,14-dichloro
2-chloro-1-(2-{2-[2-(2-chloroethoxy)ethoxy]ethoxy}ethoxy)ethane
Pentaethylene glycol dichloride

Biological Activity

[Description]:

Chloro-PEG5-chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₂₀Cl₂O₄

[ Molecular Weight ]:
275.16900

[ Exact Mass ]:
274.07400

[ PSA ]:
36.92000

[ LogP ]:
1.53040

Chloro-PEG5-chloride

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds