Karanjin

Names

[ CAS No. ]:
521-88-0

[ Name ]:
Karanjin

[Synonym ]:
Karanjin
4H-Furo[2,3-h]-1-benzopyran-4-one, 3-methoxy-2-phenyl-
3-Methoxy-2-phenyl-4H-furo[2,3-h]-1-benzopyran-4-one
3-Methoxy-2-phenyl-4H-furo[2,3-h]chromen-4-one
3-methoxy-2-phenylfuro[2,3-h]chromen-4-one
MFCD01740600
3-Methoxy-2-phenyl-4H-furo(2,3-h)(1)benzopyran-4-one

Biological Activity

[Description]:

Karanjin is a major active furanoflavonol constituent of Fordia cauliflora. Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arrest and enhance apoptosis[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> AMPK

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> AMPK

[References]

[1]. Jaiswal N, et al.Karanjin from Pongamia pinnata induces GLUT4 translocation in skeletal muscle cells in a phosphatidylinositol-3-kinase-independent manner. Eur J Pharmacol. 2011 Nov 16;670(1):22-8.

[2]. Guo JR, et al. Effects of karanjin on cell cycle arrest and apoptosis in human A549, HepG2 and HL-60 cancercells. Biol Res. 2015 Jul 26;48:40.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
463.0±45.0 °C at 760 mmHg

[ Melting Point ]:
156ºC

[ Molecular Formula ]:
C₁₈H₁₂O₄

[ Molecular Weight ]:
292.285

[ Flash Point ]:
233.8±28.7 °C

[ Exact Mass ]:
292.073547

[ PSA ]:
52.58000

[ LogP ]:
3.29

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.678

Safety Information

[ Safety Phrases ]:
S22-S24/25

[ RTECS ]:
DX1500000

[ HS Code ]:
2932999099

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%