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Tefibazumab

Names

[ CAS No. ]:
521079-87-8

[ Name ]:
Tefibazumab

Biological Activity

[Description]:

Tefibazumab is a humanized IgG1κ monoclonal antibody that binds to the surface-expressed adhesion protein clumping factor A. Tefibazumab can be used for the research of serious Staphylococcus aureus infections[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Others >> Others

[In Vitro]

Tefibazumab 具有由人 (>98%) 和鼠 (<2%) 氨基酸序列组成的可变抗原结合区。Tefibazumab 特异性识别金黄色葡萄球菌表达的 ClfA[2]。

[References]

[1]. pharmacokinetics of tefibazumab to placebo for treatment of Staphylococcus aureus bacteremia. Antimicrob Agents Chemother. 2006 Aug;50(8):2751-5.  

[2]. Reilley S, et, al. Open-label, dose escalation study of the safety and pharmacokinetic profile of tefibazumab in healthy volunteers. Antimicrob Agents Chemother. 2005 Mar;49(3):959-62.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds