4,4''-DICYANOSTILBENE

Names

[ Name ]:
4,4''-DICYANOSTILBENE

[Synonym ]:
trans-p,p'-dicyanostilbene
trans-4,4'-dicyanostilbene
4,4'-Iminobisbenzonitrile
Benzonitrile,4,4'-iminobis
4,4'-Imino-di-benzonitril
4,4'-dicyanodiphenylamine
stilbene-4,4'-dicarbonitrile
4,4'-azanediyldibenzonitrile
4,4'-imino-di-benzonitrile

Biological Activity

[Description]:

4,4'-Dicyanostilbene (compound 43) is a potent antimalarial agent against the Dd2 strain, with an EC50 of 27 nM. 4,4'-Dicyanostilbene exhibits in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA)[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Kyei-Baffour K, et, al. Natural product-inspired aryl isonitriles as a new class of antimalarial compounds against drug-resistant parasites. Bioorg Med Chem. 2020 Oct 1;28(19):115678.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₀N₂

[ Molecular Weight ]:
230.26

[ Exact Mass ]:
230.08400

[ PSA ]:
47.58000

[ LogP ]:
3.60036

Safety Information

[ HS Code ]:
2926909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%