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Cinnamopyrrolidide

Names

[ CAS No. ]:
52438-21-8

[ Name ]:
Cinnamopyrrolidide

[Synonym ]:
(2E)-3-Phenyl-1-(1-pyrrolidinyl)-2-propen-1-one
Pyrrolidine, 1-cinnamoyl-
(2E)-3-phenyl-1-(pyrrolidin-1-yl)prop-2-en-1-one
2-Propen-1-one, 3-phenyl-1-(1-pyrrolidinyl)-, (2E)-

Biological Activity

[Description]:

1-Cinnamoylpyrrolidine (Compound 3), a crude extract prepared from Piper caninum, is a DNA strand scission agent, induces the relaxation of supercoiled pBR322 plasmid DNA[1].1-Cinnamoylpyrrolidine (Compound 4) inhibits platelet aggregation induced by PAF with an IC50 of 37.3 μM[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[Target]

IC50: 37.3 μM (1-Cinnamoylpyrrolidine)[2]


[References]

[1]. Send toBioorg Med Chem.Ma J, et al. Phenolic acid amides: a new type of DNA strand scission agent from Piper caninum. Bioorg Med Chem. 2004 Jul 15;12(14):3885-9.

[2]. Chen IS, et al. Amides with anti-platelet aggregation activity from Piper taiwanense. Fitoterapia. 2007 Sep;78(6):414-9. Epub 2007 May 24.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
386.0±12.0 °C at 760 mmHg

[ Melting Point ]:
123℃

[ Molecular Formula ]:
C13H15NO

[ Molecular Weight ]:
201.264

[ Flash Point ]:
184.4±10.8 °C

[ Exact Mass ]:
201.115356

[ LogP ]:
2.18

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.606

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds