Dihydrokainic acid
Names
[ CAS No. ]:
52497-36-6
[ Name ]:
Dihydrokainic acid
[Synonym ]:
2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid
MFCD03412037
(2S,3S,4R)-3-(carboxymethyl)-4-propan-2-ylpyrrolidine-2-carboxylic acid
Dihydrokainic acid
Biological Activity
[Description]:
[Related Catalog]:
[Target]
GLT1[1]
[References]
Chemical & Physical Properties
[ Density]:
1.187g/cm3
[ Boiling Point ]:
416.6ºC at 760mmHg
[ Melting Point ]:
285 °C (dec.)
[ Molecular Formula ]:
C10H17NO4
[ Molecular Weight ]:
215.25
[ Exact Mass ]:
215.11600
[ PSA ]:
86.63000
[ LogP ]:
0.73470
[ Index of Refraction ]:
1.492
[ Storage condition ]:
2-8°C
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H312-H332
[ Precautionary Statements ]:
P280
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
20/21/22
[ Safety Phrases ]:
26-36
[ RIDADR ]:
NONH for all modes of transport
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Neurosci. 34(40) , 13472-85, (2014)
The EAAT2 glutamate transporter, accounts for >90% of hippocampal glutamate uptake. Although EAAT2 is predominantly expressed in astrocytes, ∼10% of EAAT2 molecules are found in axon terminals. Despit...
Activation of sodium-dependent glutamate transporters regulates the morphological aspects of oligodendrocyte maturation via signaling through calcium/calmodulin-dependent kinase IIβ's actin-binding/-stabilizing domain.Glia 62(9) , 1543-58, (2014)
Signaling via the major excitatory amino acid glutamate has been implicated in the regulation of various aspects of the biology of oligodendrocytes, the myelinating cells of the central nervous system...
A functional coupling between extrasynaptic NMDA receptors and A-type K+ channels under astrocyte control regulates hypothalamic neurosecretory neuronal activity.J. Physiol. 592(Pt 13) , 2813-27, (2014)
Neuronal activity is controlled by a fine-tuned balance between intrinsic properties and extrinsic synaptic inputs. Moreover, neighbouring astrocytes are now recognized to influence a wide spectrum of...