Ponicidin

Names

[ Name ]:
Ponicidin

[Synonym ]:
(1α,5β,6β,7β,8α,9β,10α,14S,20S)-1,6,7-Trihydroxy-7,20:14,20-diepoxykaur-16-en-15-one
Rubescensin B
(1S,4S,6S,8R,9R,12S,13S,16R)-6,9-Dihydroxy-7,7-dimethyl-17-methylene-3,10-dioxapentacyclo[14.2.1.0.0.0]nonadecane-2,18-dione
5H-5a,8-Methano-11H-cyclohepta[c]furo[3,4-e][1]benzopyran-5,6(7H)-dione, decahydro-2,13-dihydroxy-1,1-dimethyl-7-methylene-, (2S,3aS,5aS,8R,10aS,10bS,13R,13aR)-
5H-5a,8-Methano-11H-cyclohepta(c)furo(3,4-e)(1)benzopyran-5,6(7H)-dione, decahydro-2,13-dihydroxy-1,1-dimethyl-7-methylene-, (2S,3as,5as,7R,8R,10aS,10bS,13R,13aR)-

Biological Activity

[Description]:

Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens, and exhibits immunoregulatory, anti-inflammatory, anti-viral and anti-cancer activity. Ponicidin (Rubescensine B) induces apoptosis of gastric carcinoma cell, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on protein levels of JAK2 and STAT3[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[Target]

Apoptosis[1]

[References]

[1]. Liu YF, et al. Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. Int J Mol Sci. 2015 Jan 12;16(1):1576-89.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
580.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₆O₆

[ Molecular Weight ]:
362.417

[ Flash Point ]:
210.0±23.6 °C

[ Exact Mass ]:
362.172943

[ PSA ]:
96.22000

[ LogP ]:
3.11

[ Vapour Pressure ]:
0.0±3.7 mmHg at 25°C

[ Index of Refraction ]:
1.649

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NZ8176600

CAS REGISTRY NUMBER :: 52617-37-5

LAST UPDATED :: 199506

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H26-O6

MOLECULAR WEIGHT :: 362.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85PEAG "Zhongliu Yanjiu" Cancer Review, Yu, R., et al., eds., Shanghai Science/Technology Publisher, Peop. Rep. China, 1994 Volume(issue)/page/year: -,187,1994

Safety Information

[ Hazard Codes ]:
Xi