isoetarine

Names

[ CAS No. ]:
530-08-5

[ Name ]:
isoetarine

[Synonym ]:
Isoetarina
isoetharine
Isoetarine
Bronkosol
Isoetarin
Etyprenalinum
1-(3,4-dihydroxy-phenyl)-2-isopropylamino-butan-1-ol
Etyprenaline
Dilabron
Bronkometer
Isoetarinum

Biological Activity

[Description]:

Isoetharine (Isoetarine) is an orally active selective agonist of β-adrenergic receptors. Isoetharine is a catechol-like drug and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Inflammation/Immunology

[In Vitro]

Isoetharine (50 μM, 18 hours) can induce the production and release of [35S]sulfated metabolites of catecholic drugs in HepG2 human hepatoma cells[1].

[In Vivo]

Isoetharine inhibits melanin deposition with the AC50 value of 5.10 mM and complete inhibition of pigment production at 7.50 mM in the zebrafish larvae model[2].

[References]

[1]. Katsuhisa Kurogi，et al. Concerted actions of the catechol O-methyltransferase and the cytosolic sulfotransferase SULT1A3 in the metabolism of catecholic drugs. Biochem Pharmacol. 2012 Nov 1;84(9):1186-95.

[2]. Monika Maciag，et al. Evaluation of β-adrenergic ligands for development of pharmacological heart failure and transparency models in zebrafish. Toxicol Appl Pharmacol. 2022 Jan 1;434:115812.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₂₁NO₃

[ Molecular Weight ]:
239.31100

[ Exact Mass ]:
239.15200

[ PSA ]:
72.72000

[ LogP ]:
2.29870

Safety Information

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%