Azure A chloride

Names

[ CAS No. ]:
531-53-3

[ Name ]:
Azure A chloride

[Synonym ]:
EINECS 208-510-7
7-(Dimethylamino)-3-imino-3H-phenothiazine Hydrochloride
Methyleneazure
7-Amino-N,N-dimethyl-3H-phenothiazin-3-iminium chloride
N,N,N'-Trimethylthionin
AZURE A, CERTIFIED, PURE
Azure AC.I. 52005
Methanaminium, N-(7-amino-3H-phenothiazin-3-ylidene)-N-methyl-, chloride (1:1)
MFCD00012112
Azure A chloride

Biological Activity

[Description]:

Azure A (chloride) is a phenothiazine dye. Azure A (chlorine) is formed by oxidation of methylene blue and has strong metachromatic. Azure A (chlorine) can be used for the study of stains and redox media for electrochemical biosensing[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Snehalatha M, et al. Azure A chloride: computational and spectroscopic study[J]. Journal of Raman Spectroscopy: An International Journal for Original Work in all Aspects of Raman Spectroscopy, Including Higher Order Processes, and also Brillouin and Rayleigh Scattering, 2009, 40(2): 176-182.

[2]. Shahab S, et al. Photochromic properties of the molecule Azure A chloride in polyvinyl alcohol matrix[J]. Journal of Molecular Structure, 2015, 1101: 109-115.

Chemical & Physical Properties

[ Boiling Point ]:
442.8ºC at 760 mmHg

[ Melting Point ]:
290 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₄H₁₄ClN₃S

[ Molecular Weight ]:
291.80

[ Flash Point ]:
221.6ºC

[ Exact Mass ]:
291.059692

[ PSA ]:
70.16000

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SP5660000

CHEMICAL NAME :: Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-, chloride

CAS REGISTRY NUMBER :: 531-53-3

LAST UPDATED :: 199709

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C14-H14-N3-S.Cl

MOLECULAR WEIGHT :: 291.82

WISWESSER LINE NOTATION :: T C666 BN ISJ FZ MN1&1 &G &12/25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 37720 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59040 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 19340 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 umol/L/5H (Continuous)

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3031 No. of Facilities: 451 (estimated) No. of Industries: 4 No. of Occupations: 3 No. of Employees: 2020 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3031 No. of Facilities: 661 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 5132 (estimated) No. of Female Employees: 2765 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
SP5660000

[ HS Code ]:
2934300000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934300000

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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