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[Ala11,D-Leu15]-Orexin B TFA

Names

[ CAS No. ]:
532932-99-3

[ Name ]:
[Ala11,D-Leu15]-Orexin B TFA

[Synonym ]:
L-Methioninamide, L-arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-alanyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-
H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-D-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-ALA-GLN-ARG-LEU-D-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2
M.W. 2857.28 C120H206N44O35S
L-Arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-alanyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-L-methioninamide
(Ala11,D-Leu15)-Orexin B (human)

Biological Activity

[Description]:

[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (52 nM)[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Orexin Receptor (OX Receptor)
Research Areas >> Neurological Disease

[Target]

OX2:0.13 nM (EC50)

OX1:52 nM (EC50)


[References]

[1]. Asahi S, et al. Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B. Bioorg Med Chem Lett. 2003;13(1):111-113.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C120H206N44O35S

[ Molecular Weight ]:
2857.258

[ Exact Mass ]:
2855.541260

[ PSA ]:
1309.96000

[ LogP ]:
-10.70

[ Index of Refraction ]:
1.670

Related Compounds