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PF-4878691

Names

[ CAS No. ]:
532959-63-0

[ Name ]:
PF-4878691

[Synonym ]:
UNII-6PJC3KPK6S
N-(4-(4-Amino-2-ethyl-imidazo(4,5-c)quinolin-1-yl)butyl)methanesulfonamide
N-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methansulfonamide
852A
Methanesulfonamide, N-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]-
PF-4878691

Biological Activity

[Description]:

PF-4878691 is a potent and selective Toll-like receptor 7 (TLR7) agonist.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Infection
Research Areas >> Inflammation/Immunology

[Target]

TLR7[1]


[References]

[1]. Fidock MD, et al. The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691). Clin Pharmacol Ther. 2011 Jun;89(6):821-9.


[Related Small Molecules]

TAK-242 | Chloroquine diphosphate | Resiquimod | TLR2-IN-C29 | imiquimod | Hydroxychloroquine sulfate | GS-9620 | Motolimod | CU CPT 22 | Atractylenolide I | E6446 dihydrochloride | CU-CPT17e | Paquinimod | Gardiquimod trifluoroacetate | Procyanidin B1

Chemical & Physical Properties

[ Molecular Formula ]:
C17H23N5O2S

[ Molecular Weight ]:
361.46200

[ Exact Mass ]:
361.15700

[ PSA ]:
112.01000

[ LogP ]:
3.46030

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds