PP3

Names

[ Name ]:
PP3

[Synonym ]:
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-phenyl-
4-Amino-1-phenylpyrazolo[3,4-d]pyrimidine
MFCD00022901
1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1-phenylpyrazolo[3,4-d]pyrimidin-4-amine
4-Amino-1-phenylpyrazole[3,4-d]pyrimidine
PP3

Biological Activity

[Description]:

PP 3 (Compound 3) is an EGFR tyrosine kinase inhibitor with an IC50 of 2.7 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[References]

[1]. Traxler P, et al. Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J Med Chem. 1997 Oct 24;40(22):3601-16.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
364.0±35.0 °C at 760 mmHg

[ Melting Point ]:
214-217 °C

[ Molecular Formula ]:
C₁₁H₉N₅

[ Molecular Weight ]:
211.223

[ Flash Point ]:
173.9±25.9 °C

[ Exact Mass ]:
211.085800

[ PSA ]:
69.62000

[ LogP ]:
1.59

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.770

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn,Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S36/37/39-S26

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

PP3