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Vaccarin

Names

[ CAS No. ]:
53452-16-7

[ Name ]:
Vaccarin

[Synonym ]:
(1S)-1,5-Anhydro-2-O-α-L-arabinopyranosyl-1-{2-[4-(β-D-glucopyranosyloxy)phenyl]-5,7-dihydroxy-4-oxo-4H-chromen-6-yl}-D-glucitol
Vaccarin
D-Glucitol, 1,5-anhydro-2-O-α-L-arabinopyranosyl-1-C-[2-[4-(β-D-glucopyranosyloxy)phenyl]-5,7-dihydroxy-4-oxo-4H-1-benzopyran-6-yl]-, (1S)-

Biological Activity

[Description]:

Vaccarin is an active flavonoid glycoside associated with various biological functions. Vaccarin significantly promote wound healing and endothelial cells and fibroblasts proliferation in the wound site. Vaccarin ameliorates insulin resistance and steatosis by activating the AMPK signaling pathway[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> AMPK
Signaling Pathways >> PI3K/Akt/mTOR >> AMPK
Research Areas >> Metabolic Disease

[References]

[1]. Lei Y, et al. Vaccarin ameliorates insulin resistance and steatosis by activating the AMPK signaling pathway. Eur J Pharmacol. 2019 May 15;851:13-24.

[2]. Hou B,et al. Vaccarin hastens wound healing by promoting angiogenesis via activation of MAPK/ERK and PI3K/AKT signaling pathways in vivo. Acta Cir Bras. 2020 Feb 7;34(12):e201901202.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
1088.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C32H38O19

[ Molecular Weight ]:
726.633

[ Flash Point ]:
345.6±27.8 °C

[ Exact Mass ]:
726.200745

[ PSA ]:
319.12000

[ LogP ]:
-0.74

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.762

Safety Information

[ Safety Phrases ]:
24/25

[ HS Code ]:
29389090

Related Compounds