neorauflavane

Names

[ Name ]:
neorauflavane

[Synonym ]:
4-[(7R)-5-Methoxy-2,2-dimethyl-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-7-yl]-1,3-benzenediol
1,3-Benzenediol, 4-[(7R)-7,8-dihydro-5-methoxy-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl]-

Biological Activity

[Description]:

Neorauflavane is a potent tyrosinase inhibitor derived from Campylotropis hirtella, with an IC50 value of 30 nM for tyrosinase monophenolase activity and an IC50 value of 500 nM for diphenolase activity. Neorauflavane can effectively reduce the melanin content of B16 melanoma cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

[References]

[1]. Xuefei Tan, et al. Highly potent tyrosinase inhibitor, neorauflavane from Campylotropis hirtella and inhibitory mechanism with molecular docking. Bioorg Med Chem. 2016 Jan 15;24(2):153-9.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
552.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₂O₅

[ Molecular Weight ]:
354.40

[ Flash Point ]:
288.2±30.1 °C

[ Exact Mass ]:
354.146729

[ PSA ]:
68.15000

[ LogP ]:
3.96

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.609

Safety Information

[ Hazard Codes ]:
Xi