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metomidate

Names

[ CAS No. ]:
5377-20-8

[ Name ]:
metomidate

[Synonym ]:
DL-1-<1-Phenyl-aethyl>-imidazol-5-carbonsaeure-methylester
Methoxymol
3-(1-phenyl-ethyl)-3H-imidazole-4-carboxylic acid methyl ester
Aquacalm
R 7315
Etomidate impurity B
Metomidate [INN:BAN]
Metomidato [INN-Spanish]
(+-)-methyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate
Metomidatum [INN-Latin]
Metomidate
Methoxymol R-7315
Hypnodil

Chemical & Physical Properties

[ Density]:
1.13g/cm3

[ Boiling Point ]:
379.4ºC at 760mmHg

[ Molecular Formula ]:
C13H14N2O2

[ Molecular Weight ]:
230.26200

[ Flash Point ]:
183.2ºC

[ Exact Mass ]:
230.10600

[ PSA ]:
44.12000

[ LogP ]:
2.27900

[ Index of Refraction ]:
1.568

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NI4025000
CHEMICAL NAME :
Imidazole-5-carboxylic acid, 1-(alpha-methylbenzyl)-, methyl ester
CAS REGISTRY NUMBER :
5377-20-8
BEILSTEIN REFERENCE NO. :
0659586
LAST UPDATED :
199712
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C13-H14-N2-O2
MOLECULAR WEIGHT :
230.29
WISWESSER LINE NOTATION :
T5N CNJ AY1&R& EVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - pigeon
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - duck
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972

Safety Information

[ HS Code ]:
2933290090

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Advancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl-methoxycarbonyl metomidate in dogs.

Anesthesiology 121(6) , 1203-16, (2014)

Cyclopropyl-methoxycarbonyl metomidate (CPMM, also known as ABP-700) is a second-generation "soft" (i.e., metabolically labile) etomidate analogue. The purpose of this study was to characterize CPMM's...

Anesthesia induces stress in Atlantic salmon (Salmo salar), Atlantic cod (Gadus morhua) and Atlantic halibut (Hippoglossus hippoglossus).

Fish Physiol. Biochem. 36(3) , 719-30, (2010)

Stress in response to anesthesia with benzocaine, MS-222, metomidate and isoeugenol was studied in Atlantic salmon (Salmo salar), Atlantic halibut (Hippoglossus hippoglossus), and Atlantic cod (Gadus ...

Rates of cortisol increase and decrease in channel catfish and sunshine bass exposed to an acute confinement stressor.

Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 143(1) , 134-9, (2006)

Channel catfish and sunshine bass were exposed to a low-water stress event and allowed to recover in fresh water or a solution of metomidate (dl-1-(1-phenylethyl)-5-(metoxycarbonyl) imidazole hydrochl...


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