8-Aza-bicyclo[3.2.1]octan-3-ol HCl

Names

[ CAS No. ]:
538-09-0

[ Name ]:
8-Aza-bicyclo[3.2.1]octan-3-ol HCl

[Synonym ]:
β-Phenylethyl alcohol
b-Phenylethanol
β-Phenylethanol
3a-Nortropanol
2-Hydroxyethylbenzene
(3-endo)-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride (1:1)
Phenylethyl alcohol (USP)
endo-8-azabicyclo(3.2.1)octan-3-ol hydrochloride
β-phenylethyl alcoho
8-Aza-bicyclo[3.2.1]octan-3-ol HCl
b-pea
Nortropin
(2-Hydroxyethyl)benzene
8-Azabicyclo[3.2.1]octan-3-ol
Tropigenin
nortropenol
phenylethanol
β-Phenethyl alcohol
b-Phenylethyl alcohol
(3-endo)-8-Azabicyclo[3.2.1]octan-3-olato(2-) hydrochloride (1:1)
endo-8-Azabicyclo[3.2.1]octan-3-ol
nortropan-3endo-ol
N-Demethyltropine
PEA
N-normethyltropine
Benzeneethanol
Phenyl Ethanol
Q2R
3-hydroxy-nortropan
NOR-TROPANOL
2-Phenylethanol
b-Phenethanol
8-Azabicyclo[3.2.1]octan-3-ol, (3-endo), hydrochloride (1:1)
b-Hydroxyethylbenzene
β-PEA
Tropigenine
Phenethylalcohol
Phenylethyl alcohol
β-Hydroxyethylbenzene

Biological Activity

[Description]:

Nortropine (Nortropenol), isolated from the total alkaloids of Convolvulus subhirsutus, is an intermediate in tropine breakdown and reactions leading to succinate[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Bartholomew BA, et al. Atropine Metabolism by Pseudomonas sp. Strain AT3: Evidence for Nortropine as an Intermediate in Tropine Breakdown and Reactions Leading to Succinate. Appl Environ Microbiol. 1996 Sep;62(9):3245-50.

[2]. A. M. Gapparov, et al. Alkaloids of Convolvulus subhirsutus from Uzbekistan. Chemistry of Natural Compounds. 2007. 43(3):291-292.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
218.2±8.0 °C at 760 mmHg

[ Melting Point ]:
108-110ºC

[ Molecular Formula ]:
C₇H₁₃NO

[ Molecular Weight ]:
122.164

[ Flash Point ]:
102.2±0.0 °C

[ Exact Mass ]:
122.073166

[ PSA ]:
40.46000

[ LogP ]:
1.36

[ Vapour Pressure ]:
0.1±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.536

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RD0700000

CHEMICAL NAME :: 1-alpha-H,5-alpha-H-Nortropan-3-alpha-ol

CAS REGISTRY NUMBER :: 538-09-0

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H13-N-O

MOLECULAR WEIGHT :: 127.21

WISWESSER LINE NOTATION :: T56 A AMTJ GQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 145,97,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANCPAC Annales de Chimie. (Masson et Cie, Paris, France) V.9-15, 1914-77. Volume(issue)/page/year: 7,537,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 145,97,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANCPAC Annales de Chimie. (Masson et Cie, Paris, France) V.9-15, 1914-77. Volume(issue)/page/year: 7,537,1962

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%