Ambazone

Names

[ CAS No. ]:
539-21-9

[ Name ]:
Ambazone

[Synonym ]:
[1,4]Benzochinon-carbamimidoylhydrazon-thiosemicarbazon
Ambazona [inn-spanish]
Benzoqu
anginon
Faringosept
ambazon
[1,4]benzoquinone-carbamimidoylhydrazone thiosemicarbazone
promassol
primal
Benzochinon-(1,4)-monoguanylhydrazon-monothiosemicarbazon
Ambazona
Inversal

Biological Activity

[Description]:

Ambazone is an orally active membrane active antitumor agent. Ambazone also shows antibacterial and weak antiviral activities[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. G Löber, et al. Ambazone as a membrane active antitumor drug. Biophys Chem. 1990 Apr;35(2-3):287-300.

Chemical & Physical Properties

[ Density]:
1.57g/cm3

[ Boiling Point ]:
461.9ºC at 760mmHg

[ Melting Point ]:
195°C (rough estimate)

[ Molecular Formula ]:
C₈H₁₁N₇S

[ Molecular Weight ]:
237.28

[ Flash Point ]:
233.2ºC

[ Exact Mass ]:
237.08000

[ PSA ]:
156.76000

[ LogP ]:
1.42280

[ Index of Refraction ]:
1.761

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF5550000

CHEMICAL NAME :: Guanidine, ((4-oxo-2,5-cyclohexadien-1-ylidene)amino)-, thiosemicarbazone

CAS REGISTRY NUMBER :: 539-21-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C8-H11-N7-S

MOLECULAR WEIGHT :: 237.32

WISWESSER LINE NOTATION :: SUYZMNU- AL6Y DYJ DUNMYZUM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 315 mg/kg/5D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 840 mg/kg/28D-I

TOXIC EFFECTS :: Gastrointestinal - other changes Endocrine - changes in thymus weight Blood - changes in bone marrow (not otherwise specified)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 625 mg/kg/5D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 10 gm/L

REFERENCE :: STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1966- Volume(issue)/page/year: 117,99,1987

Safety Information

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%