Isovaleramide

Names

[ CAS No. ]:
541-46-8

[ Name ]:
Isovaleramide

[Synonym ]:
Isopentanamide
3-Methylbutyramide
Butanamide,3-methyl
dimethyl propionic acid amide
3-methylbutaneamide
MFCD00014807
Isovaleric acid amide
dimethyl propionamide
Isovaleramide
3-Methylbutanamide
3-methylbutylamide
EINECS 208-781-1
NPS 1776
Isovaleric amide

Biological Activity

[Description]:

Isovaleramide is an active principle on central nervous system from Valeriana pavonii, as an anticonvulsant.Target：in vitro: Isovaleramide (300 μM) exhibits a 42% of inhibition of the binding of 3H-FNZ to its sites.in vivo: Isovaleramide at 100 mg/Kg, p.o, evidences a 90% index protection against the maximal electroshock seizure in mice (MES).

[Related Catalog]:

Signaling Pathways >> Others >> Others

Natural Products >> Alkaloid

Research Areas >> Neurological Disease

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
0.901g/cm3

[ Boiling Point ]:
232°C

[ Melting Point ]:
135 °C

[ Molecular Formula ]:
C₅H₁₁NO

[ Molecular Weight ]:
101.14700

[ Flash Point ]:
232°C

[ Exact Mass ]:
101.08400

[ PSA ]:
43.09000

[ LogP ]:
1.21810

[ Index of Refraction ]:
1.425

[ Storage condition ]:
-20℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EJ3650000

CHEMICAL NAME :: Butanamide, 3-methyl-

CAS REGISTRY NUMBER :: 541-46-8

BEILSTEIN REFERENCE NO. :: 1740789

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C5-H11-N-O

MOLECULAR WEIGHT :: 101.17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 10,453,1975

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RTECS ]:
EJ3650000

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%