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3,4-Dimethoxychalcone

Names

[ CAS No. ]:
5416-71-7

[ Name ]:
3,4-Dimethoxychalcone

[Synonym ]:
1-phenyl-3-(3,4-dimethoxyphenyl)-2-propen-1-one
3,4-dimethoxybenzylideneacetophenone
(E)-3-(3,4-DIMETHOXYPHENYL)-1-PHENYLPROP-2-EN-1-ONE
3-(3,4-dimethoxy-phenyl)-1-propenone
3,4-Dimethoxy-chalkon
DIMETHOXYCHALCONE,3,4
3,4-dimethoxy-chalcone

Biological Activity

[Description]:

3,4-Dimethoxychalcone is a Caloric restriction mimetics (CRMs). 3,4-Dimethoxychalcone induces the deacetylation of cytoplasmic proteins and stimulates autophagy flux. 3,4-Dimethoxychalcone can be used for cardiac and cancer diseases research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Okolo EN, et al. New chalcone derivatives as potential antimicrobial and antioxidant agent. Sci Rep. 2021 Nov 5;11(1):21781.  

[2]. Chen G, et al. 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB. EMBO Mol Med. 2019 Nov 7;11(11):e10469.  

Chemical & Physical Properties

[ Density]:
1.128g/cm3

[ Boiling Point ]:
421.8ºC at 760mmHg

[ Melting Point ]:
88ºC

[ Molecular Formula ]:
C17H16O3

[ Molecular Weight ]:
268.31

[ Flash Point ]:
200.7ºC

[ Exact Mass ]:
268.11000

[ PSA ]:
35.53000

[ LogP ]:
3.59990

MSDS

Click to get detail MSDS

Related Compounds