2-Methyl-L-serine

Names

[ Name ]:
2-Methyl-L-serine

[Synonym ]:
Serine,2-methyl-,DL
2-methylserine
Serine, 2-methyl-, DL-
DL-A-METHYLSERINE
Dl-serine,2-methyl
2-methyl-DL-serine
DL-Serine, 2-methyl-
A-METHYL-D,L-SERINE
L-Serine, 2-methyl-
DL-2-Methylserine
DL-2-Me-Ser-OH
2-Methyl-L-serine
Alpha-Methyl-D,L-serine

Biological Activity

[Description]:

2-Amino-3-hydroxy-2-methylpropanoic acid is a serine derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
345.8±32.0 °C at 760 mmHg

[ Melting Point ]:
253-263ºC

[ Molecular Formula ]:
C₄H₉NO₃

[ Molecular Weight ]:
119.119

[ Flash Point ]:
162.9±25.1 °C

[ Exact Mass ]:
119.058243

[ PSA ]:
83.55000

[ LogP ]:
-1.23

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.513

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Drug design, in vitro pharmacology, and structure-activity relationships of 3-acylamino-2-aminopropionic acid derivatives, a novel class of partial agonists at the glycine site on the N-methyl-D-aspartate (NMDA) receptor complex.

J. Med. Chem. 52 , 5093-107, (2009)

Retaining agonistic activity at the glycine coagonist site of the NMDA receptor in molecules derived from glycine or d-serine has proven to be difficult because in the vicinity of the alpha-amino acid...

The requirement of phosphorylation on a threonine residue in the acute regulation of steroidogenesis in MA-10 mouse Leydig cells.

J. Steroid Biochem. Mol. Biol. 46(3) , 337-47, (1993)

In the present study we have used several non-phosphorylatable analogs of the amino acids threonine and serine to determine the role of phosphorylation in the acute regulation of steroidogenesis in MA...

Control of chemoselectivity in Dieckmann ring closures leading to tetramic acids.

Org. Biomol. Chem. 9 , 6663, (2011)

An efficient strategy for the control of the chemoselectivity in Dieckmann ring closures leading to tetramic acids derived from serine and α-methyl serine is reported, and this provides pathways to di...