NHE3-IN-3

Names

[ CAS No. ]:
543734-50-5

[ Name ]:
NHE3-IN-3

Biological Activity

[Description]:

NHE3-IN-3 (Compound 1) is a Na+/H+ exchanger isoform 3 (NHE3) inhibitor with pIC50 of 6.2 and 6.6 against human and rat NHE3, respectively. NHE3-IN-3 shows high (98%) oral bioavailability in Sprague–Dawley rats[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Metabolic Disease

[Target]

pIC50: 6.6 (rat NHE3), 6.2 (human NHE3)[1]


[References]

[1]. Jacobs JW, et al. Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3. ACS Med Chem Lett. 2022 Apr 11;13(7):1043-1051.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H16Cl2N2O2S

[ Molecular Weight ]:
371.28

Related Compounds