R-Tetrahydropapaverine

Names

[ Name ]:
R-Tetrahydropapaverine

[Synonym ]:
(R)-(-)-Norlaudanosine Hydrochloride
(R)-1-((3,4-dimethoxyphenyyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline hydrochloride
MFCD03788189
(R)-Tetrahydropapaverinehydrochloride
EINECS 415-110-8
R-(+)-TETRAHYDROPAPAVERIN HYDROCHLORIDE
http://www.gabrielpharm.com/hy/detailpro.phpid=39
(R)-1,2,3,4-tetrahydropapaverine hydrochloride
(R)-tetrahydropaverine hydrochloride
Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride (1:1)
(R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratrylisoquinoline hydrochloride
D-(-)-Norlaudanosine hydrochloride
(R)-1-(3,4-DIMETHOXY-BENZYL)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HCL
R-BINAP
1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (1:1)
R-(+)-Tetrahydropapaverin
(r)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratrylisoquinoline
R-(-)-norlaudanosine*HCl
R-tetrahydropapaverine HCl

Biological Activity

[Description]:

(R)-Tetrahydropapaverine hydrochloride is the inactive isomer of Tetrahydropapaverine hydrochloride (HY-N0137), and can be used as an experimental control. Tetrahydropapaverine hydrochloride is one of the Tetrahydroisoquinolines. Tetrahydropapaverine hydrochloride has neurotoxic effects on dopamine neurons[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Koshimura I, et al. Dimethoxyphenylethylamine and tetrahydropapaverine are toxic to the nigrostriatal system. Brain Res. 1997 Oct 31;773(1-2):108-16.

[2]. Kim EI, et al. Inhibitory effects of tetrahydropapaverine on serotonin biosynthesis in murine mastocytoma P815 cells. Life Sci. 2004 Sep 3;75(16):1949-57.

Chemical & Physical Properties

[ Density]:
1.12 g/cm3

[ Boiling Point ]:
475.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₆ClNO₄

[ Molecular Weight ]:
379.88

[ Flash Point ]:
202.7ºC

[ Exact Mass ]:
379.155029

[ PSA ]:
48.95000

[ LogP ]:
4.28130

[ Index of Refraction ]:
1.549

Safety Information

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R52/53

[ Safety Phrases ]:
S22-S61

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%