Nizofenone

Names

[ Name ]:
Nizofenone

[Synonym ]:
Nizofenone
Ekonal
EkonN
(2-Chlorophenyl)(2-{2-[(diethylamino)methyl]-1H-imidazol-1-yl}-5-nitrophenyl)methanone
(2-Chlorophenyl)[2-[2-[(diethylamino)methyl]-1H-imidazol-1-yl]-5-nitrophenyl]methanone
Y-9179
2'-Chloro-2-[2-[(diethylamino)methyl]imidazol-1-yl]-5-nitrobenzophenone
Midafenone
Methanone, (2-chlorophenyl)[2-[2-[(diethylamino)methyl]-1H-imidazol-1-yl]-5-nitrophenyl]-

Biological Activity

[Description]:

Nizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

Nizofenone (1 and 10 μM) prolongs the action potential duration of guinea-pig papillary muscle and dog Purkinje fibers[3]. Nizofenone (30 μM) suppresses the spontaneous activity of dog Purkinje fibers and guinea-pigs S-A node[3]. Nizofenone (100 μM) decreases the contractile force of guinea-pig papillary muscle[3]. Nizofenone (10 μM) inhibits the peroxidative disintegration of mitochondria (in rat brain mitochondrial suspension)[4].

[In Vivo]

Nizofenone (3 and 9 mg/kg, i.p., daily) attenuates the chronic restraint stress (CRS)-induced cognitive impairments[1]. Nizofenone (10 mg/kg i.p.) inhibits ischemia-induced glutamate increase and lactate increase in the hippocampus of rats[2]. Animal Model: Mice with chronic restraint stress[1] Dosage: 3, 9 mg/kg Administration: Intraperitoneal injection (i.p.), daily Result: Increased crossing frequencies of the open field test. Increased in the activities of enzymatic SOD and CAT.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
609.7±65.0 °C at 760 mmHg

[ Melting Point ]:
75-76°

[ Molecular Formula ]:
C₂₁H₂₁ClN₄O₃

[ Molecular Weight ]:
412.869

[ Flash Point ]:
322.5±34.3 °C

[ Exact Mass ]:
412.130219

[ PSA ]:
83.95000

[ LogP ]:
4.25

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.623

Safety Information

[ HS Code ]:
2933290090

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%