1H-Naphtho(2,3-d)-1,2,3-triazole-4,9-dione, 1-phenyl-

Names

[ Name ]:
1H-Naphtho(2,3-d)-1,2,3-triazole-4,9-dione, 1-phenyl-

Biological Activity

[Description]:

IDO1/TDO-IN-2 (Compound 1) is a potent inhibitor of IDO1/TDO with IC50s of 0.1 and 0.07 μM. IDO1/TDO-IN-2 has the potential for the research of cancer diseases[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)

[References]

[1]. Pan S, et al. Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO). Eur J Med Chem. 2020 Dec 1;207:112703.

Chemical & Physical Properties

[ Density]:
1.44g/cm3

[ Boiling Point ]:
523.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₉N₃O₂

[ Molecular Weight ]:
275.26

[ Flash Point ]:
270.3ºC

[ Exact Mass ]:
275.06900

[ PSA ]:
64.85000

[ LogP ]:
2.04270

[ Index of Refraction ]:
1.75

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%