AGROCLAVIN

Names

[ CAS No. ]:
548-42-5

[ Name ]:
AGROCLAVIN

[Synonym ]:
8,9-didehydro-6,8-dimethyl-ergolin
ERGOLINE,8,9-DIDEHYDRO-6,8-DIMETHYL
Indolo[4,3-fg]quinoline, 4,6,6a,7,8,10a-hexahydro-7,9-dimethyl-
6,8-Dimethyl-8,9-didehydro-ergolin
6,8-dimethyl-8,9-didehydro-ergoline
AGROCLAVINE
8,9-didehydro-6,8-dimethylergoline

Biological Activity

[Description]:

Agroclavine is a natural, clavine type of ergot alkaloid. Agroclavine is a D1 dopamine receptor and α1-adrenoceptor agonist. Agroclavine also has anticancer and antimicrobial activities[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

[Target]

D1 Receptor

α1-adrenergic receptor

[References]

[1]. Starec M, et al. Effect of agroclavine on NK activity in vivo under normal and stress conditions in rats. Physiol Res. 2001;50(5):513-9.

[2]. Eich E, et al. Antimicrobial activity of clavines. Arzneimittelforschung. 1985;35(12):1760-2.

Chemical & Physical Properties

[ Density]:
1.161g/cm3

[ Boiling Point ]:
422.5ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₁₈N₂

[ Molecular Weight ]:
238.32800

[ Flash Point ]:
209.3ºC

[ Exact Mass ]:
238.14700

[ PSA ]:
19.03000

[ LogP ]:
3.00580

[ Index of Refraction ]:
1.653

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KE6325000

CHEMICAL NAME :: Ergoline, 8,9-didehydro-6,8-dimethyl-

CAS REGISTRY NUMBER :: 548-42-5

BEILSTEIN REFERENCE NO. :: 0024966

LAST UPDATED :: 199709

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C16-H18-N2

MOLECULAR WEIGHT :: 238.36

WISWESSER LINE NOTATION :: T C6656 1A P GN LM DUTT&&J E1 G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 mg/kg

SEX/DURATION :: female 1-5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 20 mg/kg

SEX/DURATION :: female 3-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 2 umol/plate

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,1811,1987

Safety Information

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%