Violacein

Names

[ CAS No. ]:
548-54-9

[ Name ]:
Violacein

[Synonym ]:
(3Z)-3-[5-(5-hydroxy-1H-indol-3-yl)-2-oxo-1H-pyrrol-3-ylidene]-1H-indol-2-one

Biological Activity

[Description]:

Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[Target]

Microbial Metabolite

[In Vitro]

Violacein (0.25-3 µM; 24h; HCT116 and HT29 cells) possesses anticancer activity in both 2D and 3D cell models[1]. Violacein decreases RTKs expression and disturbs signaling pathways in CRC cells[1]. Cell Viability Assay[1]. Cell Line: HCT116 and HT29 (1.8 × 104 cells/well-100 µL) cells. Concentration: 0.25, 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 µM. Incubation Time: 24h. Result: In the 2D culture model, the violacein treatment reduced the cell viability, since there was a decrease in formazan production in the HT29 and HCT116 cell lines. Moreover, HT29 was more sensitive to violacein, as evidenced by the IC50 value (0.6 μM) compared to HCT116 (1.2 μM).

[References]

[1]. Patricia F de Souza Oliveira, et al. Violacein negatively modulates the colorectal cancer survival and epithelial-mesenchymal transition. J Cell Biochem. 2022 Jul;123(7):1247-1258.

[2]. Marlon Konzen, et al. Antioxidant properties of violacein: possible relation on its biological function. Bioorg Med Chem. 2006 Dec 15;14(24):8307-13.

Chemical & Physical Properties

[ Density]:
1.549g/cm3

[ Boiling Point ]:
821.4ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₁₃N₃O₃

[ Molecular Weight ]:
343.34

[ Flash Point ]:
450.6ºC

[ Exact Mass ]:
343.09600

[ PSA ]:
101.20000

[ LogP ]:
3.11110

[ Index of Refraction ]:
1.804

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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